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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Enhancing Tumor Content through Tumor Macrodissection
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Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features.

Marnelli A Bautista-Quach, Christopher D Ake, Mingyi Chen

    Journal of Gastrointestinal Oncology
    |September 4, 2012
    PubMed
    Summary

    Gastrointestinal lymphomas, often originating in the stomach, include MALT lymphoma and diffuse large B cell lymphoma. Early-stage MALT lymphoma associated with Helicobacter pylori infection responds well to antibiotic treatment.

    Keywords:
    Gastrointestinal lymphomasMALT lymphomaNK/T-cell enteropathy

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    Area of Science:

    • Gastroenterology
    • Hematology
    • Oncology

    Background:

    • Primary gastrointestinal lymphoma constitutes a significant portion of non-Hodgkin lymphomas and extranodal lymphomas.
    • The stomach is the most common site, followed by the small intestine and colon.
    • Key subtypes include mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma.

    Purpose of the Study:

    • To review the epidemiology, histology, and treatment of primary gastrointestinal lymphomas.
    • To highlight the role of Helicobacter pylori in MALT lymphoma and celiac disease in T cell lymphoma.
    • To discuss diagnostic and staging modalities and therapeutic strategies.

    Main Methods:

    • Literature review of primary gastrointestinal lymphomas.
    • Analysis of histological subtypes and associated conditions.
    • Evaluation of diagnostic tools like endoscopic ultrasonography and treatment outcomes.

    Main Results:

    • MALT lymphoma, often linked to H. pylori, and diffuse large B cell lymphoma are the most frequent subtypes.
    • Enteropathy-associated T cell lymphoma is associated with celiac disease.
    • Stage I MALT lymphoma with H. pylori infection shows high remission rates with antibiotic therapy.

    Conclusions:

    • Gastrointestinal lymphomas encompass diverse lymphoid neoplasms with varying prognoses.
    • Accurate diagnosis and staging are crucial for effective management.
    • Tailored treatment strategies, including antibiotics for H. pylori-positive MALT lymphoma, are essential.