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Inductively coupled plasma-MS in drug development: bioanalytical aspects and applications
Fred van Heuveln1, Henri Meijering, Jaap Wieling
1QPS Netherlands BV, Petrus Campersingel 123, 9713 AG, Groningen, The Netherlands.
Bioanalysis
|September 5, 2012
Summary
Inductively coupled plasma mass spectrometry (ICP-MS) offers a powerful alternative to LC-MS/MS for specific bioanalytical challenges in drug development. This technique excels in elemental bioanalysis and emerging applications like speciation and proteomics.
Area of Science:
- Bioanalysis
- Analytical Chemistry
- Pharmacokinetics
- Drug Development
Background:
- Modern bioanalysis heavily relies on LC-MS/MS and immunoassays for diverse molecules.
- LC-MS/MS is not always suitable for all compounds, necessitating alternative methods.
- Inductively coupled plasma mass spectrometry (ICP-MS) is an underutilized technique in drug development.
Purpose of the Study:
- To explore the analytical potential and quantitative aspects of ICP-MS in life sciences.
- To review current applications, hyphenation possibilities, and sample matrices for ICP-MS.
- To provide an outlook on ICP-MS in regulated bioanalysis and future drug development.
Main Methods:
- Review of scientific literature on ICP-MS applications in bioanalysis.
- Discussion of ICP-MS hyphenations such as LC-ICP-MS and CE-ICP-MS.
- Analysis of various sample matrices relevant to life sciences.
Main Results:
- ICP-MS is primarily used for elemental bioanalysis, imaging, mass-balance, food-effect, and biomarker studies.
- Recent applications show ICP-MS's utility in speciation/metabolism and proteomics.
- ICP-MS, with hyphenations, demonstrates versatility across different bioanalytical tasks.
Conclusions:
- ICP-MS presents a valuable alternative for specific bioanalytical needs where LC-MS/MS falls short.
- The technique's role is expanding beyond elemental analysis into metabolism and proteomics.
- ICP-MS holds significant future potential for regulated bioanalysis and drug development.
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