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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Related Experiment Video

Updated: May 19, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
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Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

[Paraneoplastic retinopathy].

Yu Liu1, Bo Lei

  • 1Department of Ophthalmology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|September 5, 2012
PubMed
Summary
This summary is machine-generated.

Paraneoplastic retinopathy (PR) involves immune reactions targeting the retina, often linked to cancer. Early diagnosis and treatment with immunosuppressants can help manage vision loss in patients with cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR).

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Last Updated: May 19, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Area of Science:

  • Ophthalmology
  • Immunology
  • Oncology

Context:

  • Paraneoplastic retinopathy (PR) encompasses cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR).
  • PR arises from immune cross-reactivity between tumor antigens and retinal neuron antigens.
  • Autoantibodies against photoreceptors cause CAR, while those against ON-bipolar cells cause MAR.

Purpose:

  • To elucidate the mechanisms of paraneoplastic retinopathy (PR).
  • To highlight the role of specific autoantibodies (e.g., recoverin) and cellular targets (e.g., TRPM1 channel) in PR pathogenesis.
  • To outline diagnostic criteria and potential therapeutic strategies for PR.

Summary:

  • PR is characterized by visual disturbances like decreased vision and night blindness.
  • Diagnosis relies on tumor history, ophthalmic symptoms, and detecting circulating antibodies.
  • Recoverin autoantibody is linked to CAR; TRPM1 channel inactivation is implicated in MAR.

Impact:

  • Understanding PR pathogenesis aids in early diagnosis and targeted treatment.
  • Immunosuppressants and glucocorticoids show potential in improving visual function.
  • This research contributes to managing paraneoplastic syndromes affecting vision.