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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

6.4K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.9K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.8K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K

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Related Experiment Video

Updated: Feb 20, 2026

Author Spotlight: Ex Vivo Protocol for Culturing Quiescent Muscle Stem Cells with Niche Components
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The stem cell niche: tissue physiology at a single cell level.

Jonathan Hoggatt1, David T Scadden

  • 1Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

The Journal of Clinical Investigation
|September 5, 2012
PubMed
Summary

Stem cells are vital for tissue repair and regeneration. Understanding their niche in hematopoiesis is key to developing systems physiology for better health outcomes.

Area of Science:

  • Physiology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Stem cells are crucial for tissue maintenance, regeneration, and repair, especially in high cell turnover tissues.
  • Stem cell regulation balances immediate injury response with long-term quiescence.
  • Stem cells govern dynamic tissue function and adapt to changing physiological needs.

Purpose of the Study:

  • To discuss the components of the stem cell niche in hematopoiesis.
  • To advocate for unbiased mapping of niche constituents under various conditions.
  • To establish a foundation for developing systems physiology.

Main Methods:

  • Literature review and discussion of stem cell niche components in hematopoiesis.

Main Results:

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Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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  • Identification of key stem cell niche components in hematopoietic system.
  • Emphasis on the need for condition-specific mapping of these components.

Conclusions:

  • Understanding the stem cell niche is fundamental to comprehending tissue physiology.
  • Unbiased mapping of the hematopoietic stem cell niche is a critical first step towards systems physiology.