Related Experiment Video
Updated: May 19, 2026
08:31
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Niosomes: novel sustained release nonionic stable vesicular systems--an overview
N B Mahale1, P D Thakkar, R G Mali
1Amrutvahini College of Pharmacy, Sangamner-422608, Dist. Ahmednagar, Maharshtra, India. nitinbmahale@yahoo.com
Advances in Colloid and Interface Science
|September 6, 2012
Summary
Niosomes are advanced drug delivery systems offering enhanced bioavailability and prolonged therapeutic effects. These non-toxic, cost-effective vesicles overcome liposome limitations, finding diverse applications in gene and anticancer drug delivery.
Area of Science:
- Pharmaceutics
- Drug Delivery Systems
- Nanotechnology
Background:
- Vesicular systems offer controlled drug delivery for enhanced bioavailability and sustained therapeutic effects.
- Niosomes, a type of vesicular system, utilize nonionic surfactants and lipids for drug encapsulation.
- Niosomes present advantages over liposomes, including lower production costs, improved stability, and reduced toxicity.
Purpose of the Study:
- To provide a comprehensive review of niosomes as a drug delivery system.
- To discuss factors influencing niosome formulation, manufacturing, and characterization.
- To compare niosomes with liposomes and highlight their applications.
Main Methods:
- Literature review of niosome technology.
- Analysis of factors affecting niosome formulation and stability.
- Comparison of niosome properties and applications with liposomes.
Main Results:
- Niosomes are stable, non-toxic, and cost-effective drug delivery vehicles.
- Various factors significantly impact niosome characteristics and performance.
- Niosomes demonstrate broad applicability in drug delivery, including gene, vaccine, and anticancer therapies.
Conclusions:
- Niosomes represent a promising alternative to liposomes for drug delivery.
- Further research into niosome formulation and application can optimize their therapeutic potential.
- Niosomes offer a versatile platform for targeted and sustained drug release.
Related Concept Videos
01:19Modified-Release Drug Delivery Systems: Overview
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
01:22Modified-Release Drug Delivery Systems: Drug Release Characteristics
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
01:26Oral Drug Delivery Systems: Continuous-Release Systems
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.