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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Idiopathic sudden sensorineural hearing loss: classic cardiovascular and new genetic risk factors

F Ballesteros1, D Tassies, J C Reverter

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Hospital Clínic, Barcelona, Spain. ferran.ballesteros@gmail.com

Audiology & Neuro-Otology
|September 6, 2012
PubMed

Insights

Idiopathic sudden sensorineural hearing loss (iSSNHL) is linked to a specific gene variant affecting platelet function. Patients with this genetic marker, particularly homozygous individuals, show a poorer recovery prognosis from iSSNHL.

Area of Science:

  • Otolaryngology
  • Genetics
  • Cardiology

Background:

  • The exact cause of idiopathic sudden sensorineural hearing loss (iSSNHL) remains unclear.
  • Clinical observations suggest vascular involvement, but direct evidence is limited due to inner ear study constraints.

Purpose of the Study:

  • To investigate the association between thrombophilic genetic variants impacting platelet function and iSSNHL.
  • To evaluate the cardiovascular risk profile in patients diagnosed with iSSNHL.

Main Methods:

  • 118 Caucasian iSSNHL patients and 161 controls underwent genetic analysis for ITGB3 (PLA1/A2) and ITGA2 (C807T) polymorphisms.
  • Cardiovascular risk was assessed using the Framingham coronary heart disease risk scale.
  • Patient recovery data was collected and analyzed in relation to genetic findings.

Main Results:

  • A higher prevalence of the ITGA2 807T allele was observed in iSSNHL patients compared to controls.
  • The homozygous ITGA2 807TT genotype correlated significantly with a reduced probability of hearing recovery.
  • No association was found between the ITGB3 PLA1/A2 polymorphism and hearing recovery.
  • Patients with iSSNHL did not exhibit an increased prevalence of traditional cardiovascular risk factors.

Conclusions:

  • The 807T thrombophilic polymorphism in platelet glycoprotein Ia/IIa is more common in iSSNHL patients.
  • Homozygosity for the ITGA2 807TT genotype is linked to diminished recovery outcomes in iSSNHL.
  • Conventional cardiovascular risk factors do not appear to be directly related to the development of iSSNHL.
Abstract

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