Related Experiment Video
Updated: May 18, 2026
07:34
Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
Published on: November 17, 2023
Differences in Postoperative Pathological Outcomes between Prostate Cancers Diagnosed at Initial and Repeat Biopsy
In Ho Khang1, Yun Beom Kim, Seung Ok Yang
1Department of Urology, Veterans Health Service Medical Center, Seoul, Korea.
Korean Journal of Urology
|September 6, 2012
Summary
Prostate cancers diagnosed via repeat biopsy showed similar pathological outcomes to those found at initial biopsy. The only significant difference was a lower percentage of tumor volume in repeat biopsy cases.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Prostate cancer (PCa) diagnosis relies on biopsy, with repeat biopsies sometimes necessary.
- Understanding pathological differences between initial and repeat biopsy diagnoses is crucial for treatment planning.
Purpose of the Study:
- To compare pathological outcomes of prostate cancers diagnosed at initial biopsy versus repeat biopsy.
Main Methods:
- Retrospective review of 287 patients undergoing radical prostatectomy (2005-2010).
- Analysis of preoperative factors and postoperative pathological outcomes.
- Classification of patients into initial (n=246) and repeat (n=41) biopsy groups.
Main Results:
- Repeat biopsy group was older, had larger prostate volume, and different biopsy schema.
- Multivariate analysis showed repeat biopsy was not an independent predictor for Gleason score, tumor bilaterality, pathological stage, positive surgical margin, lymphovascular invasion, or perineural invasion.
- Repeat biopsy was associated with a lower percentage tumor volume.
Conclusions:
- Pathological outcomes for prostate cancer detected by repeat biopsy are largely similar to those detected by initial biopsy.
- A lower percentage tumor volume is a notable difference in cancers diagnosed via repeat biopsy.
