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Updated: May 18, 2026
12:50
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Endogenous modulators of inflammatory cell recruitment
George Hajishengallis1, Triantafyllos Chavakis
1Department of Microbiology, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA, USA. geoh@upenn.edu
Trends in Immunology
|September 7, 2012
Summary
Tissues can naturally limit excessive immune cell infiltration using locally produced inhibitors. This discovery reveals a new understanding of immune regulation and tissue self-protection mechanisms.
Area of Science:
- Immunology
- Cell Biology
- Physiology
Background:
- Leukocyte recruitment is a critical immune response to inflammation.
- Previously, focus was on factors promoting leukocyte infiltration.
- Emerging evidence highlights endogenous negative regulators of this process.
Purpose of the Study:
- To introduce the emerging field of endogenous inhibitors of leukocyte extravasation.
- To propose that these inhibitors represent local homeostatic mechanisms.
- To emphasize the regulatory role of local tissues in immune responses.
Main Methods:
- Review of recent findings from inflammatory disease models.
- Analysis of evidence for locally produced modulators of leukocyte recruitment.
- Conceptual synthesis of tissue self-regulation in immunity.
Main Results:
- Identification of a new field focused on endogenous inhibitors of leukocyte extravasation.
- Demonstration of tissue self-regulation in inflammatory disease models.
- Evidence suggesting local tissues actively modulate immune cell recruitment.
Conclusions:
- Locally produced modulators are key to understanding immune self-regulation.
- These endogenous inhibitors may protect tissues from immune-mediated damage.
- Local tissue control over immune responses is more significant than previously thought.
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