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Updated: May 18, 2026
04:23
A Treatment Package without Escape Extinction to Address Food Selectivity
Published on: August 21, 2015
Summary
The TREAT Registry found that long-term infliximab treatment for Crohn's disease did not increase mortality risk. However, infliximab, corticosteroids, and narcotics were linked to a higher risk of serious infections in patients.
Area of Science:
- Gastroenterology and Hepatology
- Immunology
- Clinical Therapeutics
Background:
- The TREAT Registry provides a 5-year follow-up on Crohn's disease patients in North America, evaluating outcomes with and without infliximab treatment.
- This registry tracked over 6,000 patients, focusing on risks of mortality and serious infections to assess long-term safety profiles.
Discussion:
- Mortality rates were comparable between patients treated with infliximab and those receiving other therapies, aligning with earlier 2-year follow-up data.
- Infliximab, corticosteroids, and narcotic use were identified as factors associated with an increased risk of serious infections.
Key Insights:
- Long-term infliximab therapy in Crohn's disease patients shows similar mortality risks compared to alternative treatments.
- A significant finding is the association of infliximab, corticosteroids, and narcotics with elevated risks of serious infections.
Outlook:
- Further analysis of the TREAT Registry data may elucidate specific risk factors and inform safer treatment strategies for Crohn's disease.
- Comparative studies with other inflammatory bowel disease and rheumatoid arthritis cohorts could provide broader insights into biologic and corticosteroid safety profiles.
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