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What to take from TREAT?

Stephen B Hanauer

    The American Journal of Gastroenterology
    |September 7, 2012
    PubMed

    Insights

    The TREAT Registry found that long-term infliximab treatment for Crohn's disease did not increase mortality risk. However, infliximab, corticosteroids, and narcotics were linked to a higher risk of serious infections in patients.

    Area of Science:

    • Gastroenterology and Hepatology
    • Immunology
    • Clinical Therapeutics

    Background:

    • The TREAT Registry provides a 5-year follow-up on Crohn's disease patients in North America, evaluating outcomes with and without infliximab treatment.
    • This registry tracked over 6,000 patients, focusing on risks of mortality and serious infections to assess long-term safety profiles.

    Discussion:

    • Mortality rates were comparable between patients treated with infliximab and those receiving other therapies, aligning with earlier 2-year follow-up data.
    • Infliximab, corticosteroids, and narcotic use were identified as factors associated with an increased risk of serious infections.

    Key Insights:

    • Long-term infliximab therapy in Crohn's disease patients shows similar mortality risks compared to alternative treatments.
    • A significant finding is the association of infliximab, corticosteroids, and narcotics with elevated risks of serious infections.

    Outlook:

    • Further analysis of the TREAT Registry data may elucidate specific risk factors and inform safer treatment strategies for Crohn's disease.
    • Comparative studies with other inflammatory bowel disease and rheumatoid arthritis cohorts could provide broader insights into biologic and corticosteroid safety profiles.

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