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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: May 18, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Practical pathology of aging mice.

Christina Pettan-Brewer1, Piper M Treuting

  • 1Department of Comparative Medicine, University of Washington, Seattle, WA, USA.

Pathobiology of Aging & Age Related Diseases
|September 7, 2012
PubMed
Summary
This summary is machine-generated.

Aging mice develop lesions as part of natural decline. Understanding these age-associated diseases and lesions is crucial for humane care and accurate research outcomes in aging studies.

Keywords:
aginganimal modelscancermicepathologyveterinary pathology

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Area of Science:

  • Gerontology
  • Veterinary Pathology
  • Animal Models

Background:

  • Aging research involves maintaining mice to advanced ages (up to 33 months).
  • Older mice exhibit age-related decline, organ dysfunction, and associated welfare challenges.
  • Observable lesions are common in aging mice but vary in severity and impact.

Purpose of the Study:

  • To educate investigators on age-associated diseases and lesion patterns in mice.
  • To provide a guide for recognizing clinical, necropsy, and histopathological findings in aging mice.
  • To support the humane care and welfare of aged research animals.

Main Methods:

  • Clinical observation of aging mice by research, husbandry, and veterinary staff.
  • Necropsy and histopathological examination of lesions in aged mice.
  • Illustration of common age-associated disease presentations and lesion patterns.

Main Results:

  • Identification of common clinical signs associated with aging in mice.
  • Documentation of typical necropsy findings in aged mouse colonies.
  • Characterization of histopathological lesions prevalent in aging mouse models.

Conclusions:

  • Familiarity with age-related lesions is essential for determining humane endpoints and assessing health span.
  • Collaborative education among staff is critical for managing welfare issues in aging mouse studies.
  • This work provides a foundation for understanding and managing age-associated pathology in mice.