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Related Experiment Video

Updated: May 18, 2026

A Procedure for Implanting a Spinal Chamber for Longitudinal In Vivo Imaging of the Mouse Spinal Cord
11:20

A Procedure for Implanting a Spinal Chamber for Longitudinal In Vivo Imaging of the Mouse Spinal Cord

Published on: December 3, 2014

Spinal canal surrogate for testing intradural implants.

H Oya1, M A Howard, R Shurig

  • 1Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. hiroyuki-oya@uiowa.edu

Journal of Medical Engineering & Technology
|September 8, 2012
PubMed
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Researchers developed a novel surrogate spinal canal for testing new spinal cord stimulators. Its mock spinal cord and ligament constructs mimic human anatomy, enabling realistic performance evaluations.

Area of Science:

  • Biomedical Engineering
  • Neurosurgery
  • Medical Device Development

Background:

  • Spinal cord stimulators are crucial for treating neurological conditions.
  • Accurate preclinical testing models are needed for novel implantable devices.
  • Evaluating intradural spinal cord stimulators requires specialized anatomical surrogates.

Purpose of the Study:

  • To design and validate an anthropomorphic-scale surrogate spinal canal.
  • To assess the biomechanical properties of the surrogate's components.
  • To provide a platform for preliminary performance evaluations of novel intradural spinal cord stimulators.

Main Methods:

  • Designed and constructed an anthropomorphic-scale surrogate spinal canal.
  • Utilized a silicone mock spinal cord (10 mm x 6 mm diameters).

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Last Updated: May 18, 2026

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  • Fabricated silicone denticulate ligament constructs (300 µm thickness) to mimic anatomical restoring forces.

    • Main Results:

    • The surrogate spinal canal accurately replicates thoracic spinal cord dimensions.
    • The silicone denticulate ligament constructs provide an axial restoring force of ~0.32 N mm⁻¹ over 1.5 mm displacement.
    • This force is within a factor of 2 of human cadaveric measurements, indicating biomechanical relevance.

    Conclusions:

    • The developed surrogate spinal canal is a viable tool for preclinical assessment of spinal cord stimulators.
    • The biomimetic properties of the surrogate allow for realistic testing of intradural device performance.
    • This model facilitates the advancement of spinal cord stimulation technology through rigorous evaluation.