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Updated: May 18, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Effects of chorioamnionitis on the fetal lung
1Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML#7029, Cincinnati, OH 45229-3039, USA. alan.jobe@cchmc.org
Abstract:
Very preterm infants are commonly exposed to a chronic, often asymptomatic, chorioamnionitis that is diagnosed by histologic evaluation of the placenta only after delivery. The reported effects of these exposures on fetal lungs are inconsistent because exposure to different organisms, durations of exposure, and fetal/maternal responses affect outcomes. In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia.
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