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Updated: May 18, 2026
05:46
A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Can nitric oxide-based therapy prevent bronchopulmonary dysplasia?
Thomas M Raffay1, Richard J Martin, James D Reynolds
1Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Medical Center/University Hospitals, 11100 Euclid Avenue, Cleveland, OH 44106-6010, USA.
Clinics in Perinatology
|September 8, 2012
Summary
Understanding nitric oxide (NO) biology aids in developing targeted NO therapies. This review examines inhaled NO in preterm infants with bronchopulmonary dysplasia and future research directions.
Area of Science:
- Pulmonary Medicine
- Neonatology
- Biomedical Science
Background:
- Endogenous nitric oxide (NO) biology is increasingly understood.
- This knowledge informs the potential benefits and risks of exogenous NO administration.
- It also guides the development of novel NO-based therapeutic strategies.
Purpose of the Study:
- To review clinical trials using inhaled NO in preterm infants with bronchopulmonary dysplasia.
- To explore the biological rationale for new NO therapeutics.
- To identify future research avenues in NO-focused developmental lung disease research.
Main Methods:
- Review of clinical trial data for inhaled NO in preterm infants.
- Analysis of endogenous NO biology.
- Consideration of therapeutic applications of NO.
Main Results:
- Inhaled NO clinical trial results in preterm infants are contextualized.
- The biological basis for novel NO therapeutics is examined.
- Future research directions are identified.
Conclusions:
- Understanding NO biology is crucial for targeted NO therapies.
- Inhaled NO has been studied in preterm infants with bronchopulmonary dysplasia.
- Further research is needed to optimize NO-based treatments for developmental lung diseases.
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