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Updated: May 18, 2026
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Potentials and challenges in self-nanoemulsifying drug delivery systems
Abdul Wadood Khan1, Sabna Kotta, Shahid H Ansari
1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India. jali@jamiahamdard.ac.in
Expert Opinion on Drug Delivery
|September 8, 2012
Summary
Self-nanoemulsifying drug delivery systems (SNEDDS) enhance oral bioavailability for potent but poorly water-soluble drugs. SNEDDS offer a unique solution for formulating challenging compounds, improving drug release and enabling large-scale production.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Many potent drug candidates exhibit poor water solubility, limiting oral bioavailability.
- Self-nanoemulsifying drug delivery systems (SNEDDS) are a key strategy to overcome this challenge.
Purpose of the Study:
- To review the potential of SNEDDS for oral drug delivery.
- To discuss formulation aspects, excipient selection, and characterization of SNEDDS.
Main Methods:
- Literature review on SNEDDS formulation and applications.
- Exploration of biopharmaceutical and characterization aspects.
- Discussion on the impact of key constituents and excipients.
Main Results:
- SNEDDS can formulate poorly soluble drugs into stable nanoemulsions.
- Excipient selection critically influences SNEDDS performance.
- Characterization confirms improved drug solubility and release.
Conclusions:
- SNEDDS provide enhanced solubility and oral bioavailability for poorly water-soluble drugs.
- They offer dose uniformity in single-unit dosage forms (capsules).
- SNEDDS are suitable for large-scale production and address bioavailability issues.
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