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5-Fluorouracil neurotoxicity
D H Moore1, W C Fowler, L S Crumpler
1Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599.
Gynecologic Oncology
|January 1, 1990
Abstract:
Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.