Related Experiment Videos

Relationship between bone mineral density and serum osteoprotegerin in patients with chronic heart failure

Ying-Hsien Chen1, Yen-Wen Wu, Wei-Shiung Yang

  • 1National Taiwan University College of Medicine, Taipei, Taiwan.

Plos One
|September 8, 2012
PubMed

Insights

This study found that higher levels of osteoprotegerin (OPG) in heart failure (HF) patients are linked to lower bone mineral density (BMD), suggesting OPG could help identify individuals at risk for osteoporosis.

Area of Science:

  • Cardiology
  • Endocrinology
  • Geriatrics

Background:

  • Heart failure (HF) is associated with an increased risk of hip fractures.
  • The relationship between circulating biomarkers and bone mineral density (BMD) in chronic HF patients is not well understood.

Purpose of the Study:

  • To investigate the association between circulating biomarkers and BMD in stable chronic HF patients.
  • To explore the potential role of biomarkers in predicting osteoporosis risk in HF.

Main Methods:

  • Cross-sectional study of 115 stable chronic HF patients (left ventricular ejection fraction <45%).
  • Dual-energy x-ray absorptiometry (DEXA) for hip and lumbar spine BMD.
  • Biochemical assessments including B-type natriuretic peptide (BNP-32), myostatin, follistatin, and osteoprotegerin (OPG).

Main Results:

  • Lower hip BMD Z scores were observed in NYHA class III patients compared to NYHA class II.
  • Serum OPG levels were significantly higher in NYHA class III patients than in NYHA class I or II.
  • A significant negative association was found between serum OPG and trochanteric BMD, persisting after multivariate analysis.

Conclusions:

  • Serum OPG is inversely associated with trochanteric BMD in HF patients.
  • OPG may serve as a predictor of BMD and a potential alternative to DEXA for identifying HF patients at risk of osteoporosis.
Abstract

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...