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Related Experiment Video

Updated: May 18, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Chorioamnionitis and prematurity: a critical review.

P Martinelli¹, L Sarno, G M Maruotti

¹Department of Obstetrics & Gynaecology, High-Risk Pregnancy Unit, University Federico II of Naples, Naples, Italy. martinel@unina.it

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|September 11, 2012

Summary

Chorioamnionitis, an placental inflammation, significantly increases preterm birth risk and adverse outcomes for mothers and newborns. Early antibiotic and steroid treatment may improve neonatal health.

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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

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Published on: October 10, 2025

Area of Science:

Obstetrics and Gynecology
Perinatal Medicine
Neonatology

Background:

Chorioamnionitis is an acute inflammation of the placental membranes and chorion.
It is a significant risk factor for preterm birth, with incidence correlating to gestational age.

Purpose of the Study:

To critically review the relationship between chorioamnionitis and the risk of prematurity.
To examine the association between chorioamnionitis and adverse maternal-fetal outcomes.

Main Methods:

This study is a critical review of existing literature.
It synthesizes findings on chorioamnionitis and its impact on maternal and neonatal health.

Main Results:

Chorioamnionitis is a major risk factor for preterm birth.
Neonatal complications include sepsis, pneumonia, bronchopulmonary dysplasia, death, cerebral palsy, and intraventricular hemorrhage.
Maternal complications include labor abnormalities, C-sections, postpartum hemorrhage, and placental abruption.

Conclusions:

Chorioamnionitis is linked to significant adverse maternal, perinatal, and long-term outcomes.
The precise role of chorioamnionitis in neonatal outcomes requires further conclusive research.
Prompt antibiotic and steroid administration may enhance neonatal outcomes.