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Feline acromegaly.

Deborah S Greco1

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|September 11, 2012
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Summary
This summary is machine-generated.

Feline acromegaly, caused by excessive growth hormone, leads to diabetes mellitus and physical changes in older male cats. Pituitary adenomas are the cause, with radiation therapy being the most effective treatment.

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Area of Science:

  • Veterinary Medicine
  • Endocrinology

Background:

  • Acromegaly, or hypersomatotropism, stems from excessive growth hormone (GH) secretion in adult animals.
  • GH's anabolic effects are mediated by insulin-like growth factor 1 (IGF-1), produced in the liver.
  • Feline acromegaly is typically caused by a pituitary adenoma secreting excess GH.

Purpose of the Study:

  • To summarize the key aspects of feline acromegaly.
  • To outline the clinical presentation, diagnosis, and treatment of this condition in cats.

Main Methods:

  • Diagnosis involves measuring elevated GH and/or IGF-1 levels.
  • Imaging techniques like MRI or CT scans identify pituitary masses.
  • Treatment effectiveness is evaluated based on clinical outcomes and hormone levels.

Main Results:

  • Common clinical signs include diabetes mellitus, acral and facial enlargement, stridor, and organomegaly.
  • The condition predominantly affects older, male cats.
  • Radiation therapy has proven to be the most effective treatment to date.

Conclusions:

  • Feline acromegaly is a serious condition linked to pituitary adenomas and GH excess.
  • Early diagnosis and appropriate treatment, particularly radiation therapy, offer a fair to good prognosis.