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Depression in Parkinson's disease.

S E Starkstein1, T J Preziosi, P L Bolduc

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

The Journal of Nervous and Mental Disease
|January 1, 1990
PubMed
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Depression affects Parkinson's disease (PD) patients, particularly in early and late stages. Impaired daily activities and cognitive function are linked to depression in PD.

Area of Science:

  • Neurology
  • Psychiatry
  • Movement Disorders

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder.
  • Depression is a common comorbidity in PD, impacting quality of life.
  • The relationship between PD progression and depression requires further investigation.

Purpose of the Study:

  • To determine the prevalence and patterns of depression in Parkinson's disease outpatients.
  • To explore factors associated with depression in PD.
  • To investigate the relationship between depression, cognitive function, and daily living impairments in PD.

Main Methods:

  • A series of 105 outpatients with Parkinson's disease were assessed for depression.
  • Diagnostic criteria for major and minor depression were applied.

Related Experiment Videos

  • Patients were evaluated for activities of daily living, cognitive function, and neurological symptoms.

    • Main Results:

    • 21% of PD patients met criteria for major depression, and 20% for minor depression.
    • Depression frequency exhibited a bimodal distribution, peaking in early and late disease stages.
    • Depressed PD patients showed significantly higher impairment in daily activities and cognitive function compared to non-depressed patients.
    • Left hemisphere involvement correlated with depression in patients with unilateral symptoms.

    Conclusions:

    • Depression in early PD may be linked to left hemisphere dysfunction.
    • In later stages, depression is interrelated with daily living impairments.
    • These findings suggest potential multiple etiologies for depression in PD or that depression negatively influences disease progression.