Related Experiment Video
Updated: May 18, 2026

The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress
Published on: July 4, 2013
[Do antidepressant treatments influence self-harm and aggressive behaviors?]
Héloïse Delavenne1, Frederico Duarte Garcia, Florence Thibaut
1Centre hospitalier universitaire Charles-Nicolle, université de Rouen, unité Inserm U1073, 76031 Rouen, France. heloise.delavenne@gmail.com
Antidepressants can lower suicide risk in adults but are not recommended for children and adolescents due to increased suicide risk. Specialized care is crucial for adolescent depression treatment.
Area of Science:
- Psychiatry and Mental Health
- Pharmacology
- Clinical Psychology
Context:
- Depression is a common disorder with significant gender prevalence differences.
- General practitioners manage most antidepressant prescriptions in France.
- Antidepressant use in adults with depression or suicidal behavior is linked to decreased suicide risk.
Purpose:
- To review the efficacy and risks of antidepressant treatments.
- To highlight the specific considerations for adolescent depression and suicidal behavior.
- To examine the potential impact of antidepressants on impulsivity, aggressiveness, and activation syndromes.
Summary:
- Antidepressant treatment is effective in reducing suicide risk in adults but carries an increased risk in children and adolescents.
- Adolescent depression and suicidal behaviors necessitate specialized care and careful clinical evaluation before initiating treatment.
- While antidepressants may reduce impulsivity in some cases, their efficacy on violent behaviors is uncertain, and activation syndromes can occur.
Impact:
- Emphasizes the need for caution and specialized management in adolescent antidepressant therapy.
- Informs clinical practice regarding the differential risks and benefits of antidepressants across age groups.
- Highlights the importance of monitoring for adverse effects and substance interactions during antidepressant treatment.
Related Concept Videos
Antidepressant Drugs: MAOIs and Other Agents
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Drug Therapy
Antianxiety Medications
Antidepressant Drugs: Overview
Aggression
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...

