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Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
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Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

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Related Experiment Video

Updated: May 18, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Lipid monolayer collapse and microbubble stability.

James J Kwan1, Mark A Borden

  • 1Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309-0427, USA.

Advances in Colloid and Interface Science
|September 11, 2012
PubMed
Summary
This summary is machine-generated.

Lipid-coated microbubbles exhibit remarkable stability due to their lipid shells. Their collapse involves a cyclic crumpling and smoothing process, ultimately stabilizing at a small size, offering insights into monolayer physics.

Related Experiment Videos

Last Updated: May 18, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Area of Science:

  • Physics
  • Materials Science
  • Biotechnology

Background:

  • Microbubbles are micrometer-size gas particles in water, often stabilized by lipid shells.
  • Lipid-coated microbubbles show significant stability and unique mechanical properties.
  • Applications span food science, biotechnology, and medicine.

Purpose of the Study:

  • To connect recent findings on lipid-coated microbubble dissolution and gas exchange.
  • To integrate these observations with the physics of lipid monolayer collapse.
  • To explore the relevance to lung surfactant behavior.

Main Methods:

  • Review of current literature on lipid monolayer physics.
  • Analysis of recent observations on microbubble dissolution and gas exchange.
  • Correlation of microbubble behavior with monolayer collapse mechanisms.

Main Results:

  • Microbubble shell collapse occurs via nucleation and aggregation of microscopic folds.
  • This leads to macroscopic folding events and cyclic crumple-to-smooth transitions.
  • Lipid composition modulates this collapse behavior.

Conclusions:

  • Lipid monolayer collapse is proposed as the primary long-term stabilization mechanism for lipid-coated microbubbles.
  • Microbubbles eventually stabilize at a diameter of 1-2 μm, irrespective of initial conditions.
  • Microbubbles can serve as a model system for studying monolayer collapse phenomena.