Related Experiment Video
Updated: May 18, 2026
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
In vivo evaluation of porous hydroxyapatite/chitosan-alginate composite scaffolds for bone tissue engineering
Hyeong-Ho Jin1, Dong-Hyun Kim, Tae-Wan Kim
1School of Materials Science and Engineering, Pusan National University, San 30, Jangjeon-dong, Gumjeong-gu, Busan 609-735, Republic of Korea.
Abstract:
Porous hydroxyapatite (HAp)/chitosan-alginate composite scaffolds were prepared through in situ co-precipitation and freeze-drying for bone tissue engineering. The composite scaffolds were highly porous and interconnected with a pore size of around 50-220 μm at low concentrations of HAp. As the HAp content increased, the porosity of the scaffolds decreased from 84.98 to 74.54%. An MTT assay indicates that the obtained scaffolds have no cytotoxic effects on MG-63 cells, and that they have good biocompatibility. An implantation experiment in mouse skulls revealed that the composite scaffold provides a strong positive effect on bone formation in vivo in mice. Furthermore, that HAp/chitosan-alginate composite scaffold has been shown to be more effective for new bone generation than chitosan-alginate scaffold.
