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Depressive symptoms and frailty.

Philip D St John1, Suzanne L Tyas, Patrick R Montgomery

  • 1Section of Geriatric Medicine, Department of Medicine, and the Centre on Aging, University of Manitoba, Canada. pstjohn@hsc.mb.ca

International Journal of Geriatric Psychiatry
|September 11, 2012
PubMed
Summary

Depressive symptoms are linked to frailty in older adults, with a dose-response relationship observed. Specific symptoms like negative affect and somatic complaints showed stronger associations with frailty.

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Area of Science:

  • Gerontology
  • Psychiatry
  • Public Health

Background:

  • Frailty and depressive symptoms are prevalent conditions in the aging population.
  • A potential association between these two conditions necessitates further investigation.

Purpose of the Study:

  • To examine the association between depressive symptoms and frailty in older adults.
  • To determine if a dose-response relationship exists across the spectrum of depressive symptoms.
  • To investigate the specificity of this association concerning different dimensions of depressive symptoms.

Main Methods:

  • Secondary analysis of a population-based study involving 1751 community-living adults aged 65 and older.
  • Depressive symptoms assessed using the Center for Epidemiologic Studies-Depression (CES-D) scale.

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  • Frailty was measured on a scale from 0 (no frailty) to 3 (moderate/severe frailty).

    • Main Results:

    • A significant association was found between depressive symptoms and frailty, with a clear gradient effect observed across the CES-D scale.
    • The adjusted odds ratio for frailty per point increase in CES-D score was 1.03 (95% CI: 1.01, 1.05).
    • Positive affect, negative affect, and somatic complaints were associated with frailty, while interpersonal relations were not.

    Conclusions:

    • Depressive symptoms are independently associated with frailty in older adults.
    • The findings suggest that clinicians should screen frail older individuals for depressive symptoms.