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Laser diffraction and electron microscopy studies on inhalable liposomes generated from particulate-based
Abdelbary M A Elhissi1, Waqar Ahmed, Kevin M G Taylor
1Drug Delivery Research Group, Institute of Nanotechnology and Bioengineering, School of Pharmacy and Biomedical Sciences, School of Computing, Engineering and Physical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom.
Journal of Nanoscience and Nanotechnology
|September 12, 2012
Summary
This study introduces particulate-based proliposomes for efficient liposome generation in nebulizers. This novel technology simplifies drug delivery, achieving high phospholipid outputs without manual shaking.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Nanotechnology
Background:
- Liposomes are crucial for drug delivery but their generation and nebulization can be challenging.
- Particulate-based proliposomes offer a potential solution for simplified liposome preparation and delivery.
Purpose of the Study:
- To develop and evaluate particulate-based proliposomes for in situ generation of inhalable liposomes.
- To assess the aerosol performance and liposome characteristics from these proliposomes using a medical nebulizer.
Main Methods:
- Sucrose particles were coated with phosphatidylcholine formulations (egg or soya, with or without cholesterol) to create proliposomes.
- Liposomes were generated in situ within a Pari LC Plus nebulizer by adding an aqueous phase.
- Aerosol output, phospholipid delivery, droplet size, and impinger deposition were analyzed.
Main Results:
- All proliposome formulations yielded high aerosol and phospholipid outputs.
- Liposomes were successfully generated in situ within the nebulizer.
- The soya phosphatidylcholine with cholesterol (SPC:Chol) formulation showed increased nebulizer accumulation and broader droplet size distribution during sputtering.
Conclusions:
- Particulate-based proliposome technology provides a simple and effective method for generating high outputs of inhalable liposomes.
- In situ liposome generation within a medical nebulizer is feasible, simplifying the drug delivery process.