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Updated: May 18, 2026

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Travel-associated skin disease.

Rachael Morris-Jones¹, Stephen Morris-Jones

¹Dermatology Department, Kings College Hospital, Kings College London, London, UK. Rachael.morris-jones@nhs.net

Infectious Disease Clinics of North America

|September 12, 2012

Summary

Travel-associated skin diseases are common in returning travelers. Widespread rashes may signal systemic infections, while localized lesions often result from direct injury or infection.

Area of Science:

Dermatology
Infectious Diseases
Travel Medicine

Background:

Skin conditions are a frequent reason for medical consultation among travelers returning from trips.
Cutaneous eruptions can manifest as widespread rashes or localized lesions, each with distinct underlying causes and diagnostic approaches.

Purpose of the Study:

To differentiate between widespread and localized travel-associated skin diseases.
To outline the typical clinical presentations and diagnostic strategies for each type of travel-related skin condition.

Main Methods:

Clinical observation and case review of travelers presenting with skin disease.
Categorization of skin manifestations into widespread eruptions versus localized lesions.
Summary of standard diagnostic investigations, including blood tests, serology, skin biopsy, culture, and histology.

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

Main Results:

Widespread rashes often indicate systemic infections or allergic reactions, frequently accompanied by fever and malaise.
Localized skin lesions typically arise from bites, stings, or direct inoculation of pathogens, with patients usually feeling generally well.
Diagnostic workup differs: blood tests for systemic symptoms, skin biopsy for localized issues.

Conclusions:

Distinguishing between widespread and localized travel-related skin disease is crucial for appropriate diagnosis and management.
Systemic symptoms (fever, malaise) accompanying widespread rashes suggest internal pathology requiring serological investigation.
Localized lesions warrant investigation of the specific site through biopsy and culture to identify local causes.