Related Experiment Video
Updated: May 18, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
Published on: March 14, 2014
[Efficacy of diuretics in the treatment of Morbihan's disease: three cases]
1Service de dermatologie, université de Franche-Comté, CHU Saint-Jacques, Inserm U1098, SFR FED 4234-IBCT, 2, place Saint-Jacques, 25030 Besançon cedex, France.
Background:
Morbihan's disease (MD), also known as 'persistent facial oedema' or 'rosaceous lymphoedema', is an uncommon facial condition that is difficult to treat. Its cause remains unclear.
Aim:
We report three new cases of solid persistent facial oedema, which, after treatment with furosemide, showed dramatic improvement.
Patients And Methods:
Three men (respectively aged 38, 66 and 76 years) presented Morbihan's disease progressing respectively for 2, 5 and 8 years. These patients presented with facial oedema, mainly affecting the eyelids. The diagnosis of MD was based on clinical and laboratory criteria (after exclusion of other aetiologies such as sarcoidosis, lupus erythematosus, facial demodicidosis and rosacea). After several unsuccessful treatments (tetracyclines, synthetic antimalarials, danazol, systemic steroids and isotretinoin), the patients received diuretics: furosemide (60 mg/d) in two cases and spironolactone 75 mg twice daily for the third patient. The patients were evaluated after 1 month, then every 3 months.
Results:
Regression of oedema was complete or almost complete with follow-up of between 1 and 16 years. No adverse effects were reported.
Discussion:
Treatment of Morbihan's disease remains difficult and empirical. Diuretics may be of value since they help significantly reduce swelling even if they do not definitely cure patients.
Related Concept Videos
Heart Failure Drugs: Diuretics
Antihypertensive Drugs: Action of Diuretics
Heart Failure V: Medical Management
Mitral Regurgitation III: Medical Management
Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Nephrotic Syndrome III : Nursing Management

