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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

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Updated: May 18, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

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Published on: April 13, 2015

The telomere syndromes.

Mary Armanios1, Elizabeth H Blackburn

  • 1Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. marmani1@jhmi.edu

Nature Reviews. Genetics
|September 12, 2012
PubMed
Summary
This summary is machine-generated.

Telomere dysfunction causes degenerative disorders like pulmonary fibrosis and bone marrow failure. Understanding telomere syndromes offers insights into aging and common age-related diseases.

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Last Updated: May 18, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
11:29

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
11:21

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Published on: August 30, 2024

Area of Science:

  • Genetics and Molecular Biology
  • Gerontology
  • Cell Biology

Background:

  • Mounting evidence links telomere dysfunction to various degenerative disorders.
  • Diseases such as idiopathic pulmonary fibrosis and bone marrow failure share a common underlying defect: short telomeres.
  • These clinically diverse conditions collectively form a spectrum of telomere syndromes.

Purpose of the Study:

  • To review the clinical manifestations of telomere syndromes.
  • To explore the unique genetic underpinnings of these syndromes.
  • To discuss the molecular mechanisms and implications for age-related diseases.

Main Methods:

  • Literature review of studies on telomere syndromes.
  • Analysis of genetic data associated with telomere-related disorders.
  • Synthesis of molecular mechanisms underlying telomere dysfunction.

Main Results:

  • Telomere syndromes present with diverse clinical features but share a common genetic basis related to telomere maintenance.
  • Specific genetic mutations and pathways are identified as causative factors.
  • Telomere dysfunction is a significant contributor to cellular aging and degenerative processes.

Conclusions:

  • Telomere syndromes represent a distinct group of genetic disorders.
  • Understanding these syndromes provides crucial insights into the biology of aging.
  • Targeting telomere dysfunction may offer therapeutic strategies for age-related diseases.