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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
A R Moser1, H C Pitot, W F Dove
1McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706.
Science (New York, N.Y.)
|January 19, 1990
Abstract:
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.