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Updated: May 18, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
[Related factors on patients with depression related to Alzheimer's disease based on the improved cumulative logistic
Yan-hong Luo1, Zhi-xin Guo, Jin-yao Wang
1The Department of Health Statistics, Shanxi Medical University, Taiyuan 030001, China.
Objective:
To explore the determinants of Alzheimer's disease (AD) patients with depression.
Methods:
The degree of depression on AD patients was assessed by the geriatric depression scale. Improved cumulative logistic regression (ICLR) was used to analyze the determinants of AD patients with depression.
Results:
196 AD patients were investigated. Among the 196 AD patients, there were 60 (30.6%) males and 136 (69.4%) females, at 58 - 89 years of age (72.3 ± 6.0). Physical activity, diabetes, MoCA, hearing, economic sources and alcohol were related to the degree of depression of AD patients (P < 0.10). The difference between "normal" and "mild depression" was smaller than difference between "mild depression" and "severe depression".
Conclusion:
AD patients with mild depression were the target population for prevention and they were influenced by several factors listed above.
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