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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Respiratory viral infections in pediatric solid organ and hematopoietic stem cell transplantation

Defne Arslan1, Lara Danziger-Isakov

  • 1Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA, dea18@case.edu.

Current Infectious Disease Reports
|September 13, 2012
PubMed

Insights

Pediatric transplant recipients frequently experience respiratory viruses. This review examines their prevalence, risks, and the impact of infections like RSV and influenza, alongside prevention and treatment strategies.

Area of Science:

  • Pediatric critical care
  • Infectious diseases
  • Transplant medicine

Background:

  • Respiratory viruses pose significant threats to immunocompromised children.
  • Pediatric transplant recipients, including solid organ (SOT) and hematopoietic stem cell (HSCT) recipients, are particularly vulnerable.
  • Understanding viral epidemiology in these populations is crucial for effective management.

Purpose of the Study:

  • To review the prevalence and risk factors of respiratory viral infections in pediatric SOT and HSCT recipients.
  • To address the associated morbidity and mortality in these vulnerable patients.
  • To report on current prevention and treatment strategies for common respiratory viruses.

Main Methods:

  • Comprehensive literature review of studies on pediatric transplant recipients and respiratory viral infections.
  • Analysis of data on prevalence, risk factors, clinical outcomes, and therapeutic interventions.
  • Focus on specific viruses such as respiratory syncytial virus, adenovirus, and influenza.

Main Results:

  • Respiratory viruses are common in pediatric SOT and HSCT recipients.
  • Specific risk factors and significant morbidity/mortality are associated with these infections.
  • Evidence-based prevention and treatment options are available but require tailored approaches.

Conclusions:

  • Prompt identification and management of respiratory viruses are essential in pediatric transplant patients.
  • Tailored prevention and treatment strategies are critical to reduce morbidity and mortality.
  • Further research is needed to optimize care for these high-risk children.

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