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Candida-associated gastric ulcer relapsing in a different position with a different appearance
1Department of Internal Medicine, Tome Municipal Hospital of Toyosato, Tome, Miyagi 987-0364, Japan. kydosarnymai@aria.ocn.ne.jp
World Journal of Gastroenterology
|September 13, 2012
Summary
This study reports the first case of recurrent gastric ulcers associated with Candida infection in an elderly patient negative for Helicobacter pylori. Candida may play a direct role in gastric ulcer formation, challenging existing medical understanding.
Area of Science:
- Gastroenterology
- Mycology
- Infectious Diseases
Background:
- Gastric ulcers are commonly associated with Helicobacter pylori infection or NSAID use.
- Candida species are typically considered opportunistic pathogens in the gastrointestinal tract.
Observation:
- An 87-year-old Japanese woman presented with a gastric submucosal tumor-like lesion with a deep ulceration.
- Biopsy revealed Candida tropicalis but not H. pylori.
- The patient had no history of peptic ulcers or NSAID use.
Findings:
- The patient was diagnosed with a Candida-associated gastric ulcer.
- After initial healing, a recurrent ulcer developed in a different location, again positive for Candida and negative for H. pylori.
- This represents the world's first reported case of recurrent Candida-associated gastric ulcer.
Implications:
- The findings suggest Candida may play a direct etiologic role in gastric ulcer formation, even in H. pylori-negative individuals without predisposing factors.
- This challenges the prevailing view of Candida's role in gastric pathology.
- Further research is warranted to explore the mechanisms of Candida-associated gastric ulceration.
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