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Related Experiment Video

Updated: May 18, 2026

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Published on: April 3, 2019

P2X7 Receptor Function in Bone-Related Cancer.

Elena Adinolfi¹, Francesca Amoroso, Anna Lisa Giuliani

¹Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.

Journal of Osteoporosis

|September 13, 2012

Summary

Extracellular ATP

Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Tumor microenvironment modulation is key in cancer progression.
Extracellular ATP (adenosine triphosphate) influences tumor growth, neovascularization, and metastasis.

Purpose of the Study:

To summarize recent findings on the expression and function of the P2X7 receptor for extracellular ATP in bone cancers.
To investigate the role of P2X7 in primary and metastatic bone tumors.

Main Methods:

Analysis of mRNA expression microchip databases.
Literature review of P2X7 receptor in bone cancer.

Main Results:

High P2X7 receptor expression is observed in primary bone tumors and other cancers (multiple myeloma, neuroblastoma, breast, prostate).

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Related Experiment Videos

Last Updated: May 18, 2026

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Published on: April 3, 2019

Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

P2X7 receptor activation triggers pathways (NFATc1, PI3K/Akt, ROCK, VEGF) in osteoblasts, promoting tumor development and osteoblastic lesions.

P2X7 receptor promotes bone resorption and osteolytic lesions via osteoclast differentiation and secretion of RANKL, matrix metalloproteases, and cathepsins.

Conclusions:

The P2X7 receptor plays a critical role in the biology of bone cancers.
Targeting the P2X7 receptor may offer therapeutic strategies for bone malignancies.