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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
[REM sleep behavior disorder (RBD)]
Ari Ylikoski1, Markku Partinen
1Laakson sairaalan neurologian poliklinikka ja Helsingin uniklinikka, Tutkimuskeskus Vitalmed.
Abstract:
REM sleep behavior disorder (RBD) is one of the most important factors predicting Parkinson's disease. Symptoms constitute vivid dreams typically characterized by ominous contents and associated muscular activity. Specific signs include the preservation of muscle tone during REM sleep as detected in polysomnography, and behavior associated with dreaming as demonstrated by video monitoring. Injury risk is increased during the attacks. Melatonin or clonazepam can be used as therapy. The disorder belongs to the entity of synucleinopathies.
Insights
REM sleep behavior disorder (RBD) predicts Parkinson's disease, featuring vivid dreams with muscle activity. Diagnosis involves polysomnography and video monitoring, with treatments like melatonin or clonazepam available.
Area of Science:
- Neurology
- Sleep Medicine
- Neurodegenerative Diseases
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