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Related Concept Videos

Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

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Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Dosing frequency and medication adherence in chronic disease.

Craig I Coleman1, Brendan Limone, Diana M Sobieraj

  • 1University of Connecticut, School of Pharmacy, 80 Seymour St., Hartford, CT 06102-5037, USA. ccolema@harthosp.org

Journal of Managed Care Pharmacy : JMCP
|September 14, 2012
PubMed
Summary

Patients with chronic diseases show better medication adherence with once-daily dosing compared to more frequent schedules. Stricter adherence measures amplify this difference, highlighting the impact of dosing frequency on medication adherence.

Related Experiment Videos

Last Updated: May 18, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Health Services Research

Background:

  • Previous research suggests decreased medication adherence with increased dosing frequency.
  • Meta-analyses have not conclusively shown an inverse relationship between dosing frequency and adherence when comparing twice-daily versus once-daily regimens.

Purpose of the Study:

  • To investigate the impact of scheduled dosing frequency on medication adherence in patients managing chronic diseases.

Main Methods:

  • Systematic literature search of Medline and Embase (1986-2011) and manual reference searches.
  • Inclusion of randomized and observational studies with prospective designs in adult patients with chronic diseases.
  • Evaluation of oral medications dosed 1-4 times daily, with adherence measured electronically for at least 1 month.
  • Meta-regression analysis using a multivariate linear mixed-model to account for random and fixed effects.

Main Results:

  • Fifty-one studies were included, analyzing adherence across different dosing frequencies.
  • Adherence rates varied significantly based on the definition used, from 80.1%-93.0% for 'taking adherence' to 18.8%-76.9% for 'timing adherence'.
  • Multivariate meta-regression revealed significantly lower adjusted adherence rates for regimens dosed more than once daily compared to once-daily regimens across all adherence definitions.

Conclusions:

  • Patients with chronic diseases demonstrate higher medication adherence with once-daily regimens compared to those requiring more frequent dosing.
  • The observed differences in adherence were more pronounced when using stringent definitions of medication adherence.