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Related Experiment Videos

Chloroquine poisoning in a child.

J C Kelly1, G S Wasserman, W D Bernard

  • 1Section of Pediatric Emergency Medicine, Children's Mercy Hospital, Kansas City, Missouri 64108.

Annals of Emergency Medicine
|January 1, 1990
PubMed
Summary

Pediatric chloroquine poisoning is highly dangerous, with a 12-month-old infant succumbing to a single tablet. This case establishes a new minimal lethal dose for children, highlighting a critical need for improved pediatric treatment protocols.

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Area of Science:

  • Toxicology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Chloroquine poisoning in children is rare but life-threatening due to a narrow therapeutic-to-toxic dose ratio.
  • Clinical manifestations in children include apnea, seizures, and cardiac arrhythmias.
  • Pediatric mortality from chloroquine poisoning is significantly higher (80%) than in adults (10%).