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Angle Closure Glaucoma: Treatment01:28

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Related Experiment Video

Updated: May 18, 2026

Surgical Correction for Pediatric Epiblepharon and Trichiasis
03:59

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Interventions for late trabeculectomy bleb leak.

Frank Bochmann1, Augusto Azuara-Blanco

  • 1Department of Ophthalmology, Cantonal Hospital of Lucerne, Lucerne, Switzerland. frank.bochmann@luks.ch.

The Cochrane Database of Systematic Reviews
|September 14, 2012
PubMed
Summary
This summary is machine-generated.

Late trabeculectomy bleb leaks can cause hypotony and infections. Conjunctival advancement surgery appears more effective than amniotic membrane transplants for treating these leaks, though more research is needed.

Related Experiment Videos

Last Updated: May 18, 2026

Surgical Correction for Pediatric Epiblepharon and Trichiasis
03:59

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Surgical Complications

Background:

  • Late bleb leaks are a frequent complication following filtering glaucoma surgery.
  • These leaks, even if asymptomatic, can lead to hypotony and increase the risk of bleb-related infections.

Purpose of the Study:

  • To evaluate the effectiveness of different interventions for managing late trabeculectomy bleb leaks.

Main Methods:

  • A systematic search of multiple databases (CENTRAL, MEDLINE, EMBASE, mRCT, ClinicalTrials.gov, ICTRP) was conducted up to July 2012.
  • Included were randomized and quasi-randomized trials comparing treatments for late bleb leaks.
  • Data were independently assessed and extracted by two authors.

Main Results:

  • One multicenter trial involving 30 participants was included.
  • The trial compared conjunctival advancement and amniotic membrane transplant for bleb leak repair.
  • Conjunctival advancement demonstrated greater efficacy in sealing filtering bleb leaks.

Conclusions:

  • Limited evidence exists regarding the comparative effectiveness of various treatments for bleb leaks.
  • Conjunctival advancement was found to be superior to amniotic membrane transplantation in the single trial reviewed.
  • Further randomized trials are necessary to compare surgical and non-surgical interventions and validate current findings, recommending comparison against conjunctival advancement as the standard procedure.