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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Updated: May 18, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Transient receptor potentials (TRPs) and anaphylaxis.

Peter K Smith1, Bernd Nilius

  • 1Department of Clinical Medicine, Griffith University, Postal Address 5/123 Nerang St, Southport, Queensland 4215, Australia. pksm@mac.com

Current Allergy and Asthma Reports
|September 14, 2012
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential (TRP) channels, including TRPV1 and TRPA1, are key players in allergic responses. Their role in exercise-induced anaphylaxis and allergy modulation by TRPM4 is explored.

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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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Published on: March 17, 2015

Area of Science:

  • Ion channel research
  • Allergy and immunology
  • Cellular physiology

Background:

  • The Transient Receptor Potential (TRP) superfamily comprises ion channels crucial for cellular functions like calcium influx and depolarization.
  • Many inflammatory mediators in allergic reactions involve TRPV1 (Vanilloid) and TRPA1 (Ankyrin) channels.
  • TRP channels regulate cellular metabolism and are implicated in various physiological processes.

Purpose of the Study:

  • To review the role of TRPV1 and TRPA1 ion channels in allergic responses.
  • To investigate the potential influence of these receptors in exercise-induced anaphylaxis.
  • To briefly discuss the role of TRPM4 channels in modulating allergic reactions.

Main Methods:

  • Literature review focusing on TRPV1, TRPA1, and TRPM4 channels.
  • Analysis of existing research on TRP channel function in allergy and anaphylaxis.
  • Synthesis of information regarding cellular calcium influx and depolarization mechanisms.

Main Results:

  • TRPV1 and TRPA1 channels are significantly involved in mediating allergic reactions.
  • These TRP channels may play a role in the pathophysiology of exercise-induced anaphylaxis.
  • Activation of the TRPM4 channel can lower the allergen reaction threshold in mast cells and lymphocytes.

Conclusions:

  • TRPV1 and TRPA1 are critical ion channels in the allergic response pathway.
  • Further research into TRP channels could offer new therapeutic targets for allergies and anaphylaxis.
  • TRPM4 modulation presents a potential mechanism for influencing allergic sensitization.