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Updated: May 18, 2026

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
Published on: January 4, 2012
Ready, set, go: the EGF receptor at the pancreatic cancer starting line
Rushika M Perera1, Nabeel Bardeesy
1Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Abstract:
Acinar-to-ductal metaplasia (ADM) results from pancreatic injury or KRAS activation, and is an early step in pancreatic cancer progression. In this issue of Cancer Cell, Ardito and colleagues and Navas and colleagues demonstrate that ADM- and KRAS-driven pancreatic cancer require EGFR signaling, revealing a mechanism for developmental reprogramming that primes tumorigenesis.
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