Related Experiment Video

Updated: May 18, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Tailor-made renal cell carcinoma vaccines

Glenn Dranoff1

  • 1Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA. glenn_dranoff@dfci.harvard.edu

Cancer Cell
|September 15, 2012
PubMed

Insights

New peptide vaccines show promise in advanced kidney cancer, offering insights into antigen selection and immune response monitoring for cancer vaccine development.

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Cancer vaccines are emerging as a clinical strategy with demonstrated activity.
  • Significant challenges persist in optimizing cancer vaccine development, including antigen selection, immune stimulation, patient stratification, and response monitoring.

Purpose of the Study:

  • To investigate the clinical activity of peptide vaccines in patients with advanced renal cell carcinoma.
  • To gain insights into critical aspects of cancer vaccine design and implementation.

Main Methods:

  • A study involving advanced renal cell carcinoma patients treated with peptide vaccines.
  • Evaluation of clinical responses and immune parameters.

Main Results:

  • The study provides crucial data on the efficacy and immunological impact of peptide vaccines in this patient cohort.
  • Key insights were generated regarding antigen selection and immune stimulation strategies.

Conclusions:

  • Peptide vaccines demonstrate potential in treating advanced renal cell carcinoma.
  • The findings contribute to addressing uncertainties in cancer vaccine development and patient management.

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...