Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictive value of QoR-15 scores at hospital discharge for unplanned healthcare utilization after elective surgery: A prospective observational study.

American journal of surgery·2026
Same author

CHIP-AML22: a complex clinical trial in de novo pediatric AML patients, including a gemtuzumab ozogamicin randomization and targeted therapy with quizartinib in eligible subgroups, within the NOPHO-DB-SHIP consortium.

Trials·2026
Same author

Increased Glycation Ratio and Risk of Complications in Latent Autoimmune Diabetes in Adults Compared With Type 1 Diabetes Onset before 30 Years: A Cohort Study.

Diabetes technology & therapeutics·2026
Same author

Home is where the heart is: the case for mobile defibrillators to improve out-of-hospital cardiac arrest survival.

The New Zealand medical journal·2026
Same author

Antifungal Effect of the Proteolytic Fraction P1G10 Stabilized by Alginate-Chitosan Polyelectrolyte Complexation Against <i>Botrytis cinerea</i>.

Foods (Basel, Switzerland)·2026
Same author

Implementation of double sequential defibrillation (DSD): an Aotearoa New Zealand observational study.

Resuscitation·2026

Related Experiment Video

Updated: May 18, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Hyperandrogenism in a postmenopausal woman.

Elena García1, Víctor García-Hierro, Laura De La Maza

  • 1Sección de Endocrinología y Nutrición. Complejo Hospitalario de Burgos. Burgos. España.

Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion
|September 15, 2012
PubMed
Summary

Postmenopausal ovarian hyperthecosis causes excess androgen secretion, leading to hirsutism and virilization. This nonneoplastic disorder results from abnormal ovarian steroidogenesis regulation.

Related Experiment Videos

Last Updated: May 18, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Gynecology

Background:

  • Ovarian androgen hypersecretion is a recognized cause of hirsutism and virilization in postmenopausal women.
  • Postmenopausal ovarian hyperthecosis is a functional disorder characterized by abnormal ovarian steroidogenesis.
  • Hyperandrogenism in postmenopausal women requires careful evaluation to identify underlying causes.

Purpose of the Study:

  • To present a case of postmenopausal hyperandrogenism attributed to ovarian hyperthecosis.
  • To highlight the clinical presentation and potential mechanisms of ovarian hyperthecosis in postmenopausal women.
  • To underscore the importance of considering ovarian hyperthecosis in the differential diagnosis of virilization in this demographic.

Main Methods:

  • Case report presentation.
  • Review of clinical presentation, hormonal assays, and imaging findings.
  • Discussion of the pathophysiology of ovarian steroidogenesis in hyperthecosis.

Main Results:

  • The patient presented with symptoms of hyperandrogenism.
  • Ovarian hyperthecosis was identified as the cause of elevated androgens.
  • Abnormal regulation of ovarian steroidogenesis was implicated in the disorder.

Conclusions:

  • Ovarian hyperthecosis can manifest as a cause of hyperandrogenism in postmenopausal women.
  • This condition represents a nonneoplastic functional disorder of the ovaries.
  • Recognition and diagnosis of ovarian hyperthecosis are crucial for appropriate management of postmenopausal hyperandrogenism.