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Updated: May 18, 2026

Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats
Published on: April 7, 2023
Adipose tissue-derived mesenchymal stem cells: a fat chance of curing kidney disease?
1Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. fl2300@columbia.edu
Abstract:
Many kidney diseases are associated with inflammation and altered immune response. Mesenchymal stem cells (MSCs) are known for their anti-inflammatory properties and immune modulation. Demonstration that the phenotype and immunosuppressive ability of adipose tissue-derived MSCs are not affected by human kidney disease or uremic serum might have clinical significance if autologous adipose tissue-derived MSCs can be tested to prove their long-term safety and efficacy in treating kidney disease.
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The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...