Incompatibility between propericiazine oral solution and tea-based drink.

Area of Science:

• Pharmaceutical Sciences
• Drug Interactions
• Food Chemistry

Background:

• Oral solutions of antipsychotic drugs require careful consideration of potential incompatibilities with common beverages.
• Tea-based drinks contain polyphenols that may interact with active pharmaceutical ingredients.

Purpose of the Study:

• To investigate the incompatibility between propericiazine (PCZ) oral solution and various commercially available tea-based drinks.
• To identify the factors responsible for the observed decline in PCZ content upon mixing with tea.

Main Methods:

• Propericiazine oral solution was mixed with different types of bottled tea-based drinks.
• Residual PCZ content, pH, and physical appearance (cloudiness, precipitation) were monitored over 24 hours.
• Specific tea polyphenol compounds, (-)-epigallocatechin gallate and (-)-epigallocatechin, were tested for interaction with PCZ.

Main Results:

• Mixing PCZ oral solution with tea-based drinks led to a significant decline in residual PCZ content, ranging from approximately 30% to 50%.
• The reduction in PCZ content occurred immediately after mixing and remained stable for 24 hours.
• The interaction with (-)-epigallocatechin gallate, a key component of green tea polyphenol, caused a 60-75% decrease in PCZ content, while (-)-epigallocatechin did not.
• Mixtures became cloudy and precipitated, with pH increasing from 3.8 to 4.5-5.1.

Conclusions:

• Propericiazine (PCZ) content is significantly reduced when diluted in tea-based drinks due to chemical interactions.
• The galloyl group present in tea polyphenols, such as (-)-epigallocatechin gallate, is responsible for the degradation of PCZ.
• Patients should be advised against mixing PCZ oral solutions with tea-based beverages to ensure therapeutic efficacy.