Giant cranial osteoma: successful staged excision of the largest reported

Craniofacial osteomas are benign, slow-growing neoplasms of the craniofacial region that are usually asymptomatic. Uncommonly, giant craniofacial osteomas may be symptomatic and cause serious morbidity including ophthalmologic problems, cerebral compression, pneumocephalus, and seizures. We present a case of a 15-year-old Asian adolescent girl with a giant cranial osteoma (17.5 × 13.2 × 5 cm: significantly larger than previously reported). She also had multiple other synchronous giant osteomas of the face causing facial asymmetry. These osteomas were resected in a multiple-staged approach with a good aesthetic and functional outcome.