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Updated: May 18, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Development of an experimental model of cardiac failure combined with type I diabetes mellitus
S A Afanasiev1, D S Kondratyeva, S V Popov
1Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
Abstract:
The doses and mode of streptozotocin injection for modeling heart failure combined with type 1 diabetes mellitus have been determined. Combined disease was induced in animals by injecting the selected streptozotocin dose (60 mg/kg intraperitoneally) at the stage of heart failure formation (2 weeks after coronary occlusion). This protocol of experiment led to development of hyperglycemia, body weight loss, and formation of myocardial cicatrix and hypertrophy corresponding to signs of heart failure paralleled by diabetes mellitus.
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