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Updated: May 18, 2026

Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Two new alkylresorcinols from Homalomena wendlandii and their cytotoxic activity
Luis A Sánchez1, Dionisio Olmedo, José Luis López-Pérez
1Center for Pharmacognostic Research on Panamanian Flora (CIFLORPAN), College of Pharmacy, University of Panama, Calle Manuel Espinosa Batista, 0824-00172, Estafeta Universitaria, Panamá, República de Panamá.
Abstract:
In the course of our search for antineoplasic agents from Panamanian Flora, two new alkylresorcinols: 1-(2,6-dihydroxyphenyl)octan-l-one (1) and (+)-1-(3-(1-(2,6-dihydroxyphenyl)butyl)-2,6-dihydroxyphenyl)octan-l-one (2), together with three known compounds, (1R, 2R)-l-(benzo[d][1,3]dioxol-5-yl)propane-1,2,3-triol (3), (+)-aptosimon (4) and (-)-sesamin (5), were identified from the leaves of Homalomena wendlandii Schott (Araceae). Their structures were established by 1D and 2D NMR and IR spectroscopic, and MS methods. Compound 2 exhibited IC50 values of 3.3, 5.8 and 4.0 microg/mL against MCF-7, SF-268 and H-460 cancer human cell lines, respectively.
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