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Related Experiment Video

Updated: May 18, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Hybrid peripheral nerve sheath tumor.

Shih-Shan Lang¹, Eric L Zager, Thomas M Coyne

¹Department of Neurosurgery, Pennsylvania Hospital, Philadelphia, Pennsylvania 19104, USA. shihshan.lang@uphs.upenn.edu

Journal of Neurosurgery

|September 18, 2012

Summary

This case report details a rare hybrid peripheral nerve tumor with both neurofibroma and schwannoma elements. The patient had multiple painful tumors without genetic predisposition, suggesting a new syndrome.

Area of Science:

Neurology
Oncology
Pathology

Background:

Hybrid peripheral nerve tumors are extremely rare, with reported cases involving combinations of neurofibroma, schwannoma, and perineurioma.

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Published on: August 25, 2023

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Last Updated: May 18, 2026

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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

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Published on: August 25, 2023

These tumors are often associated with genetic conditions like neurofibromatosis Type 1 or Type 2, or schwannomatosis.