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Heart Failure II: Pathophysiology

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Updated: May 18, 2026

Isolation of Atrial Myocytes from Adult Mice

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

Natriuretic peptides in aortic stenosis.

Paulo Torres-Ramalho¹, José Paulo Araújo, Paulo Bettencourt

¹Serviço de Medicina Interna, Hospital de São João, Porto, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology

|September 18, 2012

Summary

Natriuretic peptides show promise as biomarkers for aortic stenosis (AS), correlating with disease severity and prognosis. Further research is needed to establish their routine clinical use in managing this common heart valve disease.

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Area of Science:

Cardiology
Biomarkers
Valvular Heart Disease

Background:

Aortic stenosis (AS) is the most common valvular heart disease in developed nations.
Current diagnosis and monitoring rely on clinical and echocardiographic data.
Management of severe asymptomatic AS requires improved strategies.

Purpose of the Study:

To review the utility and prognostic significance of natriuretic peptides in aortic stenosis.
To explore the role of natriuretic peptides as complementary diagnostic tools.

Main Methods:

Literature review focusing on natriuretic peptides (NPs) in aortic stenosis (AS).
Analysis of studies investigating B-type natriuretic peptide (BNP) and NT-proBNP in AS patients.

Main Results:

Natriuretic peptides (BNP and NT-proBNP) correlate with AS severity.
NPs are associated with symptom development and patient prognosis in AS.
Established value of NPs in heart failure, coronary heart disease, and pulmonary hypertension.

Conclusions:

Natriuretic peptides hold potential as valuable prognostic biomarkers in aortic stenosis.
Additional prospective studies are required for routine clinical integration of NPs in AS management.