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Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Allergic Reactions02:06

Allergic Reactions

Overview
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...

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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Evidence-based practice: sublingual immunotherapy for allergic rhinitis.

Sarah K Wise1, Rodney J Schlosser

  • 1Otolaryngology-Head and Neck Surgery, Emory University, 550 Peachtree Street, MOT 9th Floor, Atlanta, GA 30308, USA.

Otolaryngologic Clinics of North America
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

This review covers allergic rhinitis, examining its public health and economic effects. It discusses diagnostic methods, allergy testing, and the evidence for sublingual immunotherapy (SLIT) in various patient groups.

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Area of Science:

  • Allergy and Immunology
  • Public Health
  • Pharmacoeconomics

Background:

  • Allergic rhinitis significantly impacts public health and economies globally.
  • Accurate diagnosis and effective treatment are crucial for managing this condition.
  • Sublingual immunotherapy (SLIT) offers a potential therapeutic option.

Purpose of the Study:

  • To review the current evidence on the public health and economic burden of allergic rhinitis.
  • To discuss diagnostic approaches, including allergy skin testing nuances.
  • To evaluate the evidence supporting sublingual immunotherapy (SLIT) for allergic rhinitis.

Main Methods:

  • Comprehensive literature review of existing evidence.
  • Analysis of diagnostic methods and allergy skin testing protocols.
  • Examination of clinical trial data on sublingual immunotherapy (SLIT).

Main Results:

  • Allergic rhinitis poses a substantial public health and economic challenge.
  • Current diagnostic methods, including skin testing, require careful protocol adherence.
  • Evidence supports SLIT efficacy across different age groups and allergen types, with considerations for dosing and safety.

Conclusions:

  • Effective management of allergic rhinitis requires understanding its impact and utilizing appropriate diagnostics.
  • Sublingual immunotherapy (SLIT) is a viable treatment option with a growing evidence base.
  • Further research into optimal SLIT protocols and long-term outcomes is warranted.