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Enhanced delivery of baicalein using cinnamaldehyde cross-linked chitosan nanoparticle inducing apoptosis
Varukattu Nipun Babu1, Soundarapandian Kannan
1Proteomics and Molecular Cell Physiology Lab, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore 641046, Tamil Nadu, India. nipunbabu@gmail.com
Abstract:
The chitosan (CS) nanoparticles, baicalein loaded chitosan nanoparticles were prepared by crosslinking method in a W/O emulsion system, using cinnamaldehyde as crosslinking agent. The FT-IR result showed the binding of anticancer compound baicalein to the nanoparticles. The TEM analysis revealed that the particles are spherical in nature. Zeta potential revealed negative charge of the particles. Ultraviolet spectrum analysis described that higher loading efficiency and encapsulation efficiency as 9.1% and 97.2%, respectively. In vitro baicalein release profile demonstrated the delivery of baicalein from the CS nanoparticles is a two stage process. RT-PCR and cell culture was carried out accordingly.