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Related Experiment Video

Updated: May 18, 2026

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats
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Multisystem neuroprosthetic training improves bladder function after severe spinal cord injury.

Maya Horst1, Janine Heutschi, Rubia van den Brand

  • 1Laboratory for Tissue Engineering and Stem Cell Therapy, Department of Urology, University of Zurich, Zurich, Switzerland.

The Journal of Urology
|September 18, 2012
PubMed
Summary

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Multisystem neuroprosthetic training improved bladder function in rats with spinal cord injury. This training counteracted neurogenic bladder dysfunction, preserving bladder health and preventing complications.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Urology

Background:

  • Severe spinal cord injury (SCI) often results in neurogenic bladder dysfunction.
  • Previous research developed a multisystem neuroprosthetic training program to restore locomotion after SCI.

Purpose of the Study:

  • To investigate the impact of multisystem neuroprosthetic training on the development of posttraumatic bladder dysfunction following severe SCI.

Main Methods:

  • Adult rats with SCI underwent either multisystem neuroprosthetic training or no training.
  • Urodynamics, kidney function tests (creatinine, cystatin C), and bladder morphological/histological analyses were performed at 8 weeks post-injury.

Main Results:

  • Trained rats showed preserved bladder morphology compared to untrained rats, which exhibited detrusor hypertrophy.

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Last Updated: May 18, 2026

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  • Bladder capacity increased significantly in both trained and untrained rats, but nonvoiding contractions were lower in trained rats.
  • Nerve density increased in trained rats, while afferent nerve proportion and Neuropeptide Y positive fibers decreased in trained and untrained rats, respectively.

    • Conclusions:

    • Multisystem neuroprosthetic training effectively counteracts neurogenic bladder dysfunction after severe SCI.
    • This training may help preserve bladder function and prevent long-term complications in SCI patients.